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Integrating common and rare genetic variation in diverse human populations. Kiran Musunuru, Alanna Strong, +27 authors, Maria Frank-Kamenetsky, Noemi E Lee, Tim Ahfeldt, Katherine V Sachs, Xiaoyu Li, Hui Li, Nicolas Kuperwasser, Vera M Ruda, James P Pirruccello, Brian Muchmore, Ludmila Prokunina-Olsson, Jennifer L Hall, Eric E Schadt, Carlos R Morales, Sissel Lund-Katz, Michael C Phillips, Jamie Wong, William Cantley, Timothy Racie, Kenechi G Ejebe, Marju Orho-Melander, Olle Melander, Victor Koteliansky, Kevin Fitzgerald, Ronald M Krauss, Chad A Cowan, Sekar Kathiresan, Daniel J Rader.

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PMID: 20502484 Free PMC article.ДЇrom noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. International Multiple Sclerosis Genetics Consortium (IMSGC), David R Booth, +40 authors, Robert N Heard, Graeme J Stewart, Mathew Cox, Rodney J Scott, Jeannette Lechner-Scott, An Goris, Rita Dobosi, BГ©nГ©dicte Dubois, Janna Saarela, Virpi LeppГ¤, Leena Peltonen, Tuula Pirttila, Isabelle Cournu-Rebeix, Bertrand Fontaine, Laura Bergamaschi, Sandra D'Alfonso, Maurizio Leone, Aslaug R Lorentzen, Hanne F Harbo, Elisabeth G Celius, Anne Spurkland, Jenny Link, Ingrid Kockum, Tomas Olsson, Jan Hillert, Maria Ban, Amie Baker, Anu Kemppinen, Stephen Sawcer, Alastair Compston, Neil P Robertson, Philip L De Jager, David A Hafler, Lisa F Barcellos, Adrian J Ivinson, Jacob L McCauley, Margaret A Pericak-Vance, Jorge R Oksenberg, Stephen L Hauser, David Sexton, Jonathan Haines. Lack of support for association between the KIF1B rs10492972 variant and multiple sclerosis. Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS.Дan L Nicolae, Eric Gamazon, +3 authors, Wei Zhang, Shiwei Duan, M Eileen Dolan, Nancy J Cox. Nucleic Acids Res, 2009 Nov 13 38(Database issue). JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles.Д®lodie Portales-Casamar, Supat Thongjuea, +7 authors, Andrew T Kwon, David Arenillas, Xiaobei Zhao, Eivind Valen, Dimas Yusuf, Boris Lenhard, Wyeth W Wasserman, Albin Sandelin. Heng Li, Bob Handsaker, +7 authors, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin, 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Michael E Symonds, Sylvain P Sebert, Melanie A Hyatt, Helen Budge. Nutritional programming of the metabolic syndrome. Our results suggest pervasive involvement of regulatory DNA variation in common human disease and provide pathogenic insights into diverse disorders. We also demonstrated tissue-selective enrichment of more weakly disease-associated variants within DHSs and the de novo identification of pathogenic cell types for Crohn's disease, multiple sclerosis, and an electrocardiogram trait, without prior knowledge of physiological mechanisms. Disease-associated variants systematically perturb transcription factor recognition sequences, frequently alter allelic chromatin states, and form regulatory networks. We identified distant gene targets for hundreds of variant-containing DHSs that may explain phenotype associations. Eighty-eight percent of such DHSs are active during fetal development and are enriched in variants associated with gestational exposure-related phenotypes. We show that these variants are concentrated in regulatory DNA marked by deoxyribonuclease I (DNase I) hypersensitive sites (DHSs). Genome-wide association studies have identified many noncoding variants associated with common diseases and traits.